ADMINISTRATIVE RESOURCE

We have designed the NCANDA Administrative Resource to be the hub of core decision making for the NCANDA, to build collaborative effort and communication, to maximize efficiency, and to allow for ongoing creativity and rapid dissemination of findings to the scientific community and public. In particular, the NCANDA Administrative Resource provides the organizational framework for management, direction, and overall coordination of the consortium, including the Scientific Advisory Board, Steering Committee, National Community Advisory Board, Dispute Resolution Process, as well as subcommittees of these organizations. This Resource facilitates communication between Research Project Component sites (UCSD, Duke, SRI, Pittsburgh, OHSU) and Data Analysis, Integration, and Informatics Component. The Administrative Resource coordinates protocol refinement, cross-site standardization, and reliability, including training and implementation of neuropsychological and clinical assessments, and ongoing reliability/integrity evaluation. A primary responsibility of the Resource is to assess and ensure progress towards consortium goals and facilitate decisions regarding future directions in collaboration with the Steering Committee and Scientific Advisory Board. Resource leadership designs and implements policies and procedures for access to collaborative project resources. In these ways, the NCANDA Administrative Resource ensures the quality of the science being conducted and the success of our efforts to understand the impact of alcohol on neurodevelopment of youth.

PROJECT UPDATES

NCANDA Annual Joint Steering Committee and Scientific Advisory Board Meeting October 2015
This year's Steering and Scientific Advisory Board Meeting was held in Bethesda, MD on October 28th and 29th. Participants included NCANDA lead investigators, SAB members, and NIH colleagues. The two main foci of the meeting were to review the progress that NCANDA has made toward its goals and to prepare for the upcoming competitive grant renewal.

Dr. Brown lauded the consortium for consistently maintaining the highest standards of project execution at all sites and noted the exceptional progress that has been made, including numerous publications in peer-reviewed journals. She reviewed the journal articles published in 2014-2015 that examine NCANDA’s initial research findings. A methods-focused paper detailed NCANDA’s methodology and research goals as well as the subject population’s baseline demographic characteristics and substance use involvement (Brown et al., 2015; in Journal of Studies on Alcohol and Drugs). Analysis of baseline MRI neuropsychological data allowed NCANDA investigators to examine the impact of sex, ethnicity, puberty, age, and alcohol consumption on adolescent brain development (Pfefferbaum et al., 2015; in Cerebral Cortex), and cognitive/emotional control and motor performance (Sullivan et al, 2016; in Neuropsychology). Additionally, lead investigators of the NCANDA Data Analysis Resource produced papers that delineate NCANDA’s complex centralized data integration and management system (Rohfling, Cummins, Henthorn, Chu, & Nichols, 2014; in Journal of the American Medical Informatics Association) and critique the software applications used by NCANDA to streamline electronic data capture, storage, and sharing (Nichols & Pohl, 2015, in Neuropsychology Review).

Investigators also gave updates on specific aspects of the project. Dr. Tapert reviewed very impressive subject follow-up rates: 91% of Year 1 follow-ups were completed and 80% Year 2 follow-ups, which are still underway, have been completed so far. Dr. Pohl detailed the work that the Data Analysis Resource has put into all aspects of data management. Dr. Clark presented new analyses on the Behavior Rating Inventory of Executive Function (BRIEF). Dr. DeBellis presented new data on trauma, stress and neuroimaging results. Dr. Nagel shared novel ideas for how risk phenotypes could be analyzed. Dr. Colrain presented new NCANDA polysomnography data and described pilot work on wearable devices to measure sleep in youth. Dr. Sullivan reported on the NCANDA neuropsychological data.

Dr. George Koob, Director of the National Institute on Alcohol Abuse and Alcoholism, presented an appraisal of the NCANDA progress to date. He congratulated the consortium on the quality of the work that has been produced, and suggested that NCANDA is a landmark study. He also expressed the importance of having the project continue with a grant renewal so that the NCANDA sample can be studied over a longer period of time.

The discussion then turned to the future of NCANDA. The consortium will submit a new grant to the NIH that will focus on developmentally appropriate research questions tailored for the NCANDA sample (who are now all late adolescents or young adults) to continue the project beyond its current termination date of 6/30/2017. Investigators discussed important new domains to measure in the older cohort. For example, there will be greater focus on the impact of heavy alcohol use on young adult outcomes, stress, life events, economic wellbeing, and physical fitness. New methods of remote data collection will include subjects wearing Fitbits and using mobile phone apps to assess recent substance use in vivo. Genetic samples will continue to be collected each year from each participant, for a future R01 application focused on genetics and epigenetics in the NCANDA sample.

NCANDA ADMINISTRATIVE RESOURCE LEADERSHIP

Sandra A. Brown, Ph.D. is the NCANDA Consortium Coordinator, Principal Investigator for the NCANDA Administrative Resource, and Co-investigator for the San Diego site. Dr. Brown is Vice Chancellor of Research and a Distinguished Professor of Psychiatry & Psychology at the University of California, San Diego.

Susan F. Tapert, Ph.D. is the San Diego site Principal Investigator, and Co- Principal Investigator for the Administrative Resource of NCANDA. Dr. Tapert is Professor and Associate Vice Chair of Psychiatry at the University of California, San Diego.

Bonnie J. Nagel, Ph.D. is the Oregon site Principal Investigator and Associate Director for the Administrative Resource of NCANDA. Dr. Nagel is an Associate Professor of Psychiatry and Behavioral Neuroscience at Oregon Health & Science University.

Duncan B. Clark, M.D., Ph.D. is the Pittsburgh site Principal Investigator and Associate Director for the Administrative Resource of NCANDA. Dr. Clark is an Associate Professor of Psychiatry and Pharmaceutical Sciences at the University of Pittsburgh.

Ty Brumback, Ph.D. is a Co-Investigator for the Administrative Resource of NCANDA and a Postdoctoral Fellow in the Department of Psychiatry at the University of California, San Diego.

Patrick Mercier, Ph.D. is a Co-Investigator for the Administrative Resource of NCANDA Assistant Professor in Electrical and Computer Engineering and Co-Director of the Center for Wearable Sensors at the University of California, San Diego.

Kara Bagot, M.D. is a Co-Investigator for the Administrative Resource of NCANDA and an Assistant Professor of Psychiatry at the University of California, San Diego.

Mark Schuckit, M.D. is a Co-Investigator for the Administrative Resource of NCANDA and a Distinguished Professor of Psychiatry at the University of California, San Diego.

CONSULTANTS

Michael Kalichman, Ph.D. is a Professor of Pathology and founding Director of the Research Ethics at the University of California, San Diego.

Andrea Chiba, Ph.D. is an Associate Professor in the Department of Cognitive Science at the University of California, San Diego.

UCSD ADMINISTRATIVE RESOURCE RESEARCHERS AND STAFF

Kevin Cummins, M.S., Senior Statistician, Technology Coordinator

Sonja Eberson, M.A., Senior Administrator

CONTACT

Please fill out the form below:

Mailing Address:

Dr. Sandra Brown
Vice Chancellor for Research
University of California San Diego
9500 Gilman Drive #0862
La Jolla, CA 92093-0862

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Administrative Resource Contact:

Sonja Eberson, M.A.
Phone: 858-822-3685

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